Drug interaction is a response resulting, either desirable or undesirable, of drugs acting with themselves or other drugs, chemical agents or components of the diet.
| Medication taken | Prescription drug for dental problems | Interaction |
| Antacids | Tetracycline | Diminished Tetracycline effect |
| Anticancer (Methotrexate) | Aspirin | Increased toxicity of Methotrexate |
| Anticoagulants (Coumarins) | Tetracycline | May potentiate anticoagulants |
| Streptomycin | May potentiate anticoagulants | |
| Salicylates | Potentiates action of anticoagulants | |
| Barbiturates | Antagonizes action of anticoagulants | |
| Antidepressant (Tofranil, Elavil, Eutonyl, Parnate) | Epinephrine | Hypertensive crisis |
| Antidepressant (Marplan) | Narcotic analgesics | Enhances narcotic analgesics |
| Antidepressant (Nardil) | General Anesthetics | Enhanced CNS depression |
| Barbiturates | Enhanced CNS depression | |
| Anticonvulsives Phenytoin (Dilantin) | Phenobarbitol | Decreases the effect of anticonvulsives |
| Antidiabetics | Salicylates | Increases hypoglycemic effect |
| Antihistamines | Sedative | Increased depression, antagonized action of antihistamines |
| Antihypertensive | General anesthetics, Sedatives | Accentuates postural hypertension |
| Antiparkinsonism Levodopa (Larodopa) | Pyridoxine (Vit.B6) | Reverse effect of Levodopa |
| Sedatives and Antianxiety agents Phenobarbital (Luminal) | Antihistamines | Additive sedative effect |
| Steroid | Decreased side effect | |
| Benzodiazepines (Librium), Valium) | Barbiturates | Enhanced sedation |
| Phenothiazines (Thorazine, SParine, Compazine) | Barbiturates | Enhanced sedation |
| Antihistamines | Enhanced sedation | |
| Meperidine | Enhanced sedation, respiratory depression |
Dietary and drug interactions
Interaction between dietary and certain drugs when consume together are as follow:
- Milk, dairy products, or iron-containing vitamins with tetracycline will diminish tetracycline effect.
- Alcohol with antihistamines, results in depression
- Alcohol with Benzodiazepines (Librium, Valium), will enhance sedation, increase respiratory depression
- Alcohol with propoxyphene (Darvon) caused CNS and respiratory depression
- Alcohol with salicylates, results in gastrointestinal bleeding
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