Selected Drugs Interaction in Dentistry and and dietaries and drugs interaction

Drug interaction is a response resulting, either desirable or undesirable, of drugs acting with themselves or other drugs, chemical agents or components of the diet.

Medication taken Prescription drug for dental problems Interaction
Antacids Tetracycline Diminished Tetracycline effect
Anticancer  (Methotrexate) Aspirin Increased toxicity of Methotrexate
Anticoagulants (Coumarins) Tetracycline May potentiate anticoagulants
Streptomycin May potentiate anticoagulants
Salicylates Potentiates action of anticoagulants
Barbiturates Antagonizes action of anticoagulants
Antidepressant (Tofranil, Elavil, Eutonyl, Parnate) Epinephrine Hypertensive crisis
Narcotic analgesics Enhances narcotic analgesics
General Anesthetics Enhanced CNS depression
Barbiturates Enhanced CNS depression
Anticonvulsives Phenytoin (Dilantin) Phenobarbitol Decreases the effect of anticonvulsives
Antidiabetics Salicylates Increases hypoglycemic effect
Antihistamines Sedative Increased depression, antagonized action of antihistamines
Antihypertensive General anesthetics, Sedatives Accentuates postural hypertension
Levodopa (Larodopa)
Pyridoxine (Vit.B6) Reverse effect of Levodopa
Sedatives and Antianxiety agents
Phenobarbital (Luminal)
Antihistamines Additive sedative effect
Steroid Decreased side effect
Benzodiazepines (Librium), Valium) Barbiturates Enhanced sedation
Phenothiazines (Thorazine, SParine, Compazine) Barbiturates Enhanced sedation
Antihistamines Enhanced sedation
Meperidine Enhanced sedation, respiratory depression

Dietary and drug interactions

Interaction between dietary and certain drugs when consume together are as follow:
  • Milk, dairy products, or iron-containing vitamins with tetracycline will diminish tetracycline effect.

  • Alcohol with antihistamines, results in depression

  • Alcohol with Benzodiazepines (Librium, Valium), will enhance  sedation, increase respiratory depression

  • Alcohol with propoxyphene (Darvon) caused CNS and respiratory depression

  • Alcohol with salicylates, results in gastrointestinal bleeding

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