Promethazine HCl

Promethazine Hydrochloride is an anti-histamine that is used to treat:
  • Certain types of allergy
  • Antiemetic (anti-nausea and vomiting)
  • Sedation before surgery and relief of apprehension in both children (older than 2 years) and adults
Promethazine competes with the naturally occurring histamine in the cell receptor level, thus prevent naturally occurring histamine from binding to the cell receptor. When naturally occurring histamine cannot bind to the cell receptor to stimulate changes within the cells, no allergic symptoms can occur.

Active ingredient in Promethazine tablet contains 25 mg or 50 mg of Promethazine HCL
Inactive ingredients: Magnesium stearate, Dibasic calcium phosphate, Microcrystalline cellulose, Stearic acid, Sodium starch glycolate (in 50 mg tablet also contains Anhydrous lactose)

Drug interactions
1. Promethazine hydrochloride may increase, prolong, intensify the action of sedative/hypnotics, narcotic analgesics, anti-depressant medications. Therefore, either avoid or reduced dose of promethazine HCl when given concomitantly with the above medications.

2. Do not use epinephrine to treat hypotension associated with Promethazine HCl overdose because Promethazine has ability to reverse the vasopressor effect of epinephrine.

3. Promethazine hydrochloride taken with anticholinergic medications may increase extrapyramidal effects.

4. Promethazine hydrochloride with a pregnancy test may result in false-negative or false-positive interpretations

5. Promethazine hydrochloride may increase blood glucose in Glucose Tolerance Test result in false interpretation.

To avoid complications with Promethazine hydrochloride, report to your physicians, dentist if you are taking medications for:
  • Cold allergy
  • Sedatives
  • Narcotics
  • Sleeping
  • Muscle relaxants
  • Seizures
  • Depression
  • Anxiety
  • Depression
  • Blood thinners
  • Bladder or urinary
  • Stomach ulcer
  • Parkinson's
  • Pituitary gland tumor
  • Restless leg syndrome
Side effects:
  1. Drowsiness, dizziness
  2. Fatigue
  3. Ringing in the ears
  4. Blurred vision
  5. Nervous
  6. Tremor
  7. Insomnia
  8. Rash, dermatitis
  9. Itching
  10. Dry mouth, nausea, vomiting
  11. Trouble with walking, balancing and coordination
  12. Feeling agitated, restless
  13. Severe confusion (Delirium)
  14. Hallucination
  15. Euphoria (mood changing)
  16. Double vision (Diplopia)
  17. Seizures
  18. Hysteria
  19. Increased or decreased blood pressure
  20. Fainting
  21. Rapid heart rate, greater than 100 (Tachycardia)
  22. Slow heart rate, less than 60 beats per minute (Bradycardia)
  23. Low white blood cells
  24. Jaundice
  25. Neuroleptic malignant syndrome
  26. Respiratory depression
  27. nightmares

Before taking this pharmaceutical, consider the potential benefits and risks to other alternative options.

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